β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares
Emily L. Goldberg; Jennifer L. Asher; Ryan D. Molony; Albert C. Shaw; Caroline J. Zeiss; Chao Wang; Ludmilla A. Morozova-Roche; Raimund I. Herzog; Akiko Iwasaki; Vishwa Deep DixitRat study: Aging and lipotoxicity are two major risk factors for gout that are linked by the activation of the NLRP3 inflammasome. Neutrophil-mediated production of interleukin-1β (IL-1β) drives gouty flares that cause joint destruction, intense pain, and fever…… Collectively, our studies show that BHB, a known alternate metabolic fuel, is also an anti-inflammatory molecule that may…
Read More >>The Effects of a Low- Carbohydrate, Ketogenic Diet on The Polycystic Ovary Syndrome: a Pilot Study
John C Mavropoulos; William S Yancy; Juanita Hepburn; Eric C WestmanSingle arm: In this pilot study, a LCKD led to significant improvement in weight, percent free testosterone, LH/FSH ratio, and fasting insulin in women with obesity and PCOS over a 24 week period.
Read More >>Dietary carbohydrate restriction improves insulin sensitivity, blood pressure, microvascular function, and cellular adhesion markers in individuals taking statins
Kevin D. Ballarda, Erin E. Quanna, Brian R. Kupchaka, Brittanie M. Volka, Diana M. Kawieckia, Maria Luz Fernandez, Richard L. Seip, Carl M. Maresha, William J. Kraemera, Jeff S.VolekSingle arm perspective with 21 participants. The results of this study suggest that a CRD could be a sustainable lifestyle that complements statin treatment to improve overall cardio-metabolic risk, particularly for individuals with other risk factors indicative of metabolic syndrome, but future research is needed to determine the effects over a longer period of time.
Read More >>Can a Low-Carbohydrate Diet Improve Exercise Tolerance in McArdle Disease?
Reason SL, Westman EC, Godfrey R, Maguire EA carbohydrate-restricted diet may provide patients with McArdle disease with a consistent energy substrate for working muscles, thereby reducing the risk of muscle damage and threat of renal failure. Further research on the use of a LCKD in McArdle disease is warranted.
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