Dietary fat guidelines have no evidence base: where next for public health nutritional advice?
Zoe Harcombe, PhDDietary fat guidelines have prevailed for almost 40 years. The evidence base at the time of their introduction has been examined for the first time and found lacking. Evidence currently available provides no additional support. Public health opinion differed when the guidelines were introduced. Opposition to the guidelines is becoming more strident. Substantial increases in diet-related…
Read More >>Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-year Non-randomized Clinical Trial
Shaminie J. Athinarayanan, Rebecca N. Adams, Sarah J. Hallberg, Amy L. McKenzie, Nasir H. Bhanpuri, Wayne W. Campbell, Jeff S. Volek, Stephen D. Phinney, James P. McCarterAn open label, non-randomized, controlled study with 262 and 87 participants with T2D were enrolled in the CCI and usual care (UC) groups, respectively. Studies on long-term sustainability of low-carbohydrate approaches to treat diabetes are limited. The aim was to assess the effects of a continuous care intervention (CCI) on retention, glycemic control, weight, body…
Read More >>LDL-C does not cause cardiovascular disease: a comprehensive review of the current literature
Michel de Lorgeril, David M Diamond, Rokuro Hama, Tomohito Hamazaki, Björn Hammarskjöld, Niamh Hynes, Malcolm Kendrick, Peter H Langsjoen, Luca Mascitelli, Kilmer S McCully, Harumi Okuyama ORCID Icon, Paul J Rosch, Tore Schersten, Sherif Sultan & Ralf SundbergFor half a century, a high level of total cholesterol (TC) or low-density lipoprotein cholesterol (LDL-C) has been considered to be the major cause of atherosclerosis and cardiovascular disease (CVD), and statin treatment has been widely promoted for cardiovascular prevention. However, there is an increasing understanding that the mechanisms are more complicated and that statin…
Read More >>Fasting Lipoprotein and Postprandial Triacylglycerol Responses to a Lowcarbohydrate Diet Supplemented With n-3 Fatty Acids
Jeff S. Volek, PhD, RD; Ana L. Gómez , MS; William J. Kraemer , PhDSingle arm prospective with 10 Participants: A hypocaloric low-carbohydrate diet rich in MUFA and supplemented with n-3 fatty acids significantly reduced postabsorptive and postprandial TG in men that were not hypertriglyceridemic as a group before the diet. This may be viewed as a clinically significant positive adaptation in terms of cardiovascular risk status.
Read More >>A Randomized Trial of a Low-Carbohydrate Diet for Obesity
Gary D. Foster, PhD; Holly R. Wyatt, MD; James O. Hill, PhD; Brian G. McGuckin, EdM; Carrie Brill, BS; B. Selma Mohammed, MD, PhD; Philippe O. Szapary, MD; Daniel J. Rader, MD; Joel S. Edman, DSc; Samuel Klein, MDRCT with 63 participants: The low-carbohydrate diet produced a greater weight loss (4%) than did the conventional diet for the first six months, but the differences were not significant at one year. The lowcarbohydrate diet was associated with a greater improvement in some risk factors for coronary heart disease.
Read More >>A Randomized Trial Comparing a Very Low Carbohydrate Diet and a Calorie-Restricted Low Fat Diet on Body Weight and Cardiovascular Risk Factors in Healthy Women
Bonnie J. Brehm; Randy J. Seeley; Stephen R. Daniels; David A. D’AlessioRCT with 53 participants: Based on these data, a very low carbohydrate diet is more effective than a low fat diet for short-term weight loss and, over 6 months, is not associated with deleterious effects on important cardiovascular risk factors in healthy women.
Read More >>A Low-Carbohydrate Diet in Overweight Patients Undergoing Stable Statin Therapy Raises High-Density Lipoprotein and Lowers Triglycerides Substantially
Dietmar Gann, MD, FACC, FACPSingle arm prospective: A Low-Carbohydrate Diet in Overweight Patients Undergoing Stable Statin Therapy Raises High-Density Lipoprotein and Lowers Triglycerides Substantially
Read More >>Long Term Effects of a Ketogenic Diet in Obese Patients
Hussein M Dashti, MD PhD FICS FACS; Thazhumpal C Mathew, MSc PhD FRCPath; Talib Hussein, MB ChB; Sami K Asfar, MB ChB MD FRCSEd FACS; Abdulla Behbahani, MB ChB FRCS FACSI PhD FICS FACS; Mousa A Khoursheed, MB ChB FRCS FICS; Hilal M Al-Sayer, MD PhD FICS FACS; Yousef Y Bo-Abbas, MD FRCPC; Naji S Al-Zaid, BSc PhDSingle arm prospective with 83 participants: The present study shows the beneficial effects of a long-term ketogenic diet. It significantly reduced the body weight and body mass index of the patients. Furthermore, it decreased the level of triglycerides, LDL cholesterol and blood glucose, and increased the level of HDL cholesterol. Administering a ketogenic diet for a…
Read More >>Comparison of High-Fat and High-Protein Diets With a High- Carbohydrate Diet in Insulin-Resistant Obese Women
K. A. McAuley; C. M. HopkinsK; J. Smith; R. T. McLay; S. M. Williams; R. W. Taylor; J. I. MannRCT with 96 participants: In routine practice a reduced-carbohydrate, higher protein diet may be the most appropriate overall approach to reducing the risk of cardiovascular disease and type 2 diabetes. To achieve similar benefits on a HC diet, it may be necessary to increase fibre-rich wholegrains, legumes, vegetables and fruits, and to reduce saturated fatty acids…
Read More >>Comparison of the Atkins, Ornish, Weight Watchers, and Zone Diets for Weight Loss and Heart Disease Risk Reduction
Michael L. Dansinger, MD; Joi Augustin Gleason, MS, RD; John L. Griffith, PhD; Harry P. Selker, MD, MSPH; Ernst J. Schaefer, MDRCT with 160 participants: Each popular diet modestly reduced body weight and several cardiac risk factors at 1 year. Overall dietary adherence rates were low, although increased adherence was associated with greater weight loss and cardiac risk factor reductions for each diet group.
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